Ontology highlight
ABSTRACT:
SUBMITTER: Rathkopf DE
PROVIDER: S-EPMC5543693 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Rathkopf Dana E DE Antonarakis Emmanuel S ES Shore Neal D ND Tutrone Ronald F RF Alumkal Joshi J JJ Ryan Charles J CJ Saleh Mansoor M Hauke Ralph J RJ Bandekar Rajesh R Maneval Edna Chow EC de Boer Carla J CJ Yu Margaret K MK Scher Howard I HI
Clinical cancer research : an official journal of the American Association for Cancer Research 20170217 14
<b>Purpose:</b> To evaluate the efficacy of apalutamide before or after treatment with abiraterone acetate and prednisone (AAP) in patients with progressive metastatic castration-resistant prostate cancer (mCRPC).<b>Experimental Design:</b> Two cohorts were studied: AAP-naïve and post-AAP patients who had received ≥6 months of AAP. Patients had progressive mCRPC per rising prostate-specific antigen (PSA) and/or imaging, without prior chemotherapy exposure. All received apalutamide 240 mg/day. Pr ...[more]