Dataset Information

Stereotactic body radiotherapy for primary hepatic malignancies - Report of a phase I/II institutional study.

ABSTRACT:

Background and purpose

To report outcomes and toxicities of a single-institution phase I/II study of stereotactic body radiotherapy (SBRT) in the treatment of unresectable hepatocellular cancer (HCC) and intrahepatic cholangiocarcinoma (IHC).

Materials and methods

Patients with Child-Pugh score less than 8 were eligible. A total of 32 lesions in 26 patients were treated with SBRT. Kaplan-Meier survival analysis was performed. Toxicities were graded by CTCAEv4 criteria and response was scored by EASL guidelines.

Results

Median prescribed dose was 55Gy (range 40-55Gy) delivered in 5 fractions. Mean tumor diameter was 5.0cm and mean GTV was 107cc. Median follow-up was 8.8months with a median survival of 11.1months, and one-year overall survival was 45%. Overall response rate was 42% and one-year local control was 91%. Nine patients experienced a decline in Child-Pugh class following treatment, and two grade 5 hepatic failure toxicities occurred during study follow-up.

Conclusions

Primary hepatic malignancies not amenable to surgical resection portend a poor prognosis, despite available treatment options. Though radiation-induced liver disease (RILD) is rare following SBRT, this study demonstrates a risk of hepatic failure despite adherence to protocol constraints.

SUBMITTER: Weiner AA

PROVIDER: S-EPMC5543719 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Publications

Stereotactic body radiotherapy for primary hepatic malignancies - Report of a phase I/II institutional study.

Weiner Ashley A AA Olsen Jeffrey J Ma Daniel D Dyk Pawel P DeWees Todd T Myerson Robert J RJ Parikh Parag P

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20160823 1

<h4>Background and purpose</h4>To report outcomes and toxicities of a single-institution phase I/II study of stereotactic body radiotherapy (SBRT) in the treatment of unresectable hepatocellular cancer (HCC) and intrahepatic cholangiocarcinoma (IHC).<h4>Materials and methods</h4>Patients with Child-Pugh score less than 8 were eligible. A total of 32 lesions in 26 patients were treated with SBRT. Kaplan-Meier survival analysis was performed. Toxicities were graded by CTCAEv4 criteria and response ...[more]

PMID: 27566894

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Dataset Information

Stereotactic body radiotherapy for primary hepatic malignancies - Report of a phase I/II institutional study.

Background and purpose

Materials and methods

Results

Conclusions

Publications

Stereotactic body radiotherapy for primary hepatic malignancies - Report of a phase I/II institutional study.

Similar Datasets

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