Ontology highlight
ABSTRACT:
SUBMITTER: Gohil SH
PROVIDER: S-EPMC5543882 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Gohil Satyen Harish SH Paredes-Moscosso Solange Rosa SR Harrasser Micaela M Vezzalini Marzia M Scarpa Aldo A Morris Emma E Davidoff Andrew M AM Sorio Claudio C Nathwani Amit Chunilal AC Della Peruta Marco M
Oncoimmunology 20170517 7
We have developed a humanized bi-specific T-cell engager (BiTE) targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1), a cell surface antigen present on a range of malignancies and cancer-initiating cells. Focusing initially on pancreatic cancer, we demonstrated that our ROR1 BiTE results in T cell mediated and antigen-specific cytotoxicity against ROR1-expressing pancreatic cancer cell lines <i>in vitro</i> at exceedingly low concentrations (0.1 ng/mL) and low effector to target rati ...[more]