Ontology highlight
ABSTRACT:
SUBMITTER: Coates K
PROVIDER: S-EPMC5544000 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Coates Katie K Walsh Timothy R TR Spencer James J Hinchliffe Philip P
Acta crystallographica. Section F, Structural biology communications 20170726 Pt 8
MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanolamine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 Å resolution crystal structure of the catalytic domain of MCR-2 was determined. Variable amino acids are located distant from both the di-zinc active site and the membrane-proximal face. The exceptionally high resolution will provide an ...[more]