High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti.
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ABSTRACT:
SUBMITTER: Torquato RJS
PROVIDER: S-EPMC5544004 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti.
Torquato Ricardo J S RJS Lu Stephen S Martins Nadia Helena NH Tanaka Aparecida S AS Pereira Pedro José Barbosa PJB
Acta crystallographica. Section F, Structural biology communications 20170726 Pt 8
Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a single-domain, noncanonical Kazal-type serine proteinase inhibitor from A. aegypti that recognizes both digestive trypsin-like serine proteinases and the central protease in blood clotting, thrombin, albeit with an affinity that is three orders of magnitude lower. Here, the 1.4 Å res ...[more]
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