Ontology highlight
ABSTRACT:
SUBMITTER: Park HH
PROVIDER: S-EPMC5544006 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20170726 Pt 8
DREP4 is a nuclease from fruit fly that is involved in apoptotic DNA fragmentation. DREP4 contains a conserved CIDE domain that acts as a protein-interaction module and is critical for its function. In this study, it was found that DREP4 CIDE domains form filament-like structures in solution. The length of the highly ordered filament-like structure is dependent on the salt concentration. By adjusting the salt concentration the DREP4 CIDE domain could be crystallized, and X-ray diffraction data w ...[more]