Dataset Information

Differential Vector Competency of Aedes albopictus Populations from the Americas for Zika Virus.

ABSTRACT: To evaluate the potential role of Aedes albopictus (Skuse) as a vector of Zika virus (ZIKV), colonized mosquitoes of low generation number (? F5) from Brazil, Houston, and the Rio Grande Valley of Texas engorged on viremic mice infected with ZIKV strains originating from Senegal, Cambodia, Mexico, Brazil, or Puerto Rico. Vector competence was established by monitoring infection, dissemination, and transmission potential after 3, 7, and 14 days of extrinsic incubation. Positive saliva samples were assayed for infectious titer. Although all three mosquito populations were susceptible to all ZIKV strains, rates of infection, dissemination, and transmission differed among mosquito and virus strains. Aedes albopictus from Salvador, Brazil, were the least efficient vectors, demonstrating susceptibility to infection to two American strains of ZIKV but failing to shed virus in saliva. Mosquitoes from the Rio Grande Valley were the most efficient vectors and were capable of shedding all three tested ZIKV strains into saliva after 14 days of extrinsic incubation. In particular, ZIKV strain DakAR 41525 (Senegal 1954) was significantly more efficient at dissemination and saliva deposition than the others tested in Rio Grande mosquitoes. Overall, our data indicate that, while Ae. albopictus is capable of transmitting ZIKV, its competence is potentially dependent on geographic origin of both the mosquito population and the viral strain.

SUBMITTER: Azar SR

PROVIDER: S-EPMC5544086 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Differential Vector Competency of <i>Aedes albopictus</i> Populations from the Americas for Zika Virus.

Azar Sasha R SR Roundy Christopher M CM Rossi Shannan L SL Huang Jing H JH Leal Grace G Yun Ruimei R Fernandez-Salas Ildefonso I Vitek Christopher J CJ Paploski Igor A D IAD Stark Pamela M PM Vela Jeremy J Debboun Mustapha M Reyna Martin M Kitron Uriel U Ribeiro Guilherme S GS Hanley Kathryn A KA Vasilakis Nikos N Weaver Scott C SC

The American journal of tropical medicine and hygiene 20170801 2

To evaluate the potential role of <i>Aedes albopictu</i>s (Skuse) as a vector of Zika virus (ZIKV), colonized mosquitoes of low generation number (≤ F5) from Brazil, Houston, and the Rio Grande Valley of Texas engorged on viremic mice infected with ZIKV strains originating from Senegal, Cambodia, Mexico, Brazil, or Puerto Rico. Vector competence was established by monitoring infection, dissemination, and transmission potential after 3, 7, and 14 days of extrinsic incubation. Positive saliva samp ...[more]

PMID: 28829735

Similar Datasets

Project description:BACKGROUND:Much work has been done in recent years to determine the vector competence of Aedes albopictus (Skuse) for Zika virus (ZIKV). If competent, Ae. albopictus could become an important vector in the spread of ZIKV to areas which until now have been considered safe from the virus. Despite much speculation about Ae. albopictus' competence for ZIKV, there have been, to date, no quantitative syntheses of Ae. albopictus' competence, nor have the potentially confounding differences between studies been addressed. METHODOLOGY/ PRINCIPLE FINDINGS:This study represents a quantitative meta-analysis of the literature surrounding this topic by examining infection rates (IR) and transmission rates (TR) among sample populations of Ae. albopictus at 7 and 14 days post infection (dpi) across 15 journal articles comprising 23 studies. Our analyses examined potentially confounding variables in the studies contained therein, including: geographic origin of viral strain or mosquito population tested, whether sympatry of the tested viral strain and mosquito population was important, and freshness of blood meal. Our results suggest 1) Ae albopictus is a competent vector for ZIKV and 2) that origin of Ae. albopictus population and origin of viral strain had significant effects on the competence of Ae. albopictus to transmit ZIKV. CONCLUSIONS/ SIGNIFICANCE:These results indicate a need to further explore the effects of methodology on vector competence studies and to examine in more detail the geographic variation in the competence of Ae. albopictus for ZIKV as well as the underlying causes of said variation. The ability of Ae. albopictus to carry and transmit ZIKV also points to a need to create new vector control strategies in case of a ZIKV outbreak in an area where Ae. albopictus is prominent. Finally, this study represents a potential template for future meta-analyses in the field of vector competence, where this type of study has been under-utilized despite the abundance of relevant studies.

Dataset Information

Differential Vector Competency of Aedes albopictus Populations from the Americas for Zika Virus.

Publications

Differential Vector Competency of <i>Aedes albopictus</i> Populations from the Americas for Zika Virus.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets