Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB.
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ABSTRACT:
SUBMITTER: Schechter MC
PROVIDER: S-EPMC5544211 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB.
Schechter Marcos C MC Buac Kristina K Adekambi Toidi T Cagle Stephanie S Celli Justine J Ray Susan M SM Mehta Christina C CC Rada Balázs B Rengarajan Jyothi J
PloS one 20170804 8
Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied. Here we investigate plasma NETs levels in patients with active pulmonary tuberculosis using an ELISA assay that is suitable for high-throughput processing. We show that plasma NETs levels at baseline ...[more]
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