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Continuous immunotypes describe human immune variation and predict diverse responses.

ABSTRACT: The immune system consists of many specialized cell populations that communicate with each other to achieve systemic immune responses. Our analyses of various measured immune cell population frequencies in healthy humans and their responses to diverse stimuli show that human immune variation is continuous in nature, rather than characterized by discrete groups of similar individuals. We show that the same three key combinations of immune cell population frequencies can define an individual's immunotype and predict a diverse set of functional responses to cytokine stimulation. We find that, even though interindividual variations in specific cell population frequencies can be large, unrelated individuals of younger age have more homogeneous immunotypes than older individuals. Across age groups, cytomegalovirus seropositive individuals displayed immunotypes characteristic of older individuals. The conceptual framework for defining immunotypes suggested by our results could guide the development of better therapies that appropriately modulate collective immunotypes, rather than individual immune components.

SUBMITTER: Kaczorowski KJ

PROVIDER: S-EPMC5544312 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Continuous immunotypes describe human immune variation and predict diverse responses.

Kaczorowski Kevin J KJ Shekhar Karthik K Nkulikiyimfura Dieudonné D Dekker Cornelia L CL Maecker Holden H Davis Mark M MM Chakraborty Arup K AK Brodin Petter P

Proceedings of the National Academy of Sciences of the United States of America 20170710 30

The immune system consists of many specialized cell populations that communicate with each other to achieve systemic immune responses. Our analyses of various measured immune cell population frequencies in healthy humans and their responses to diverse stimuli show that human immune variation is continuous in nature, rather than characterized by discrete groups of similar individuals. We show that the same three key combinations of immune cell population frequencies can define an individual's imm ...[more]

PMID: 28696306

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Continuous immunotypes describe human immune variation and predict diverse responses.

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Continuous immunotypes describe human immune variation and predict diverse responses.

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