Dataset Information

Treatment experiences of Latinas after diagnosis of breast cancer.

ABSTRACT: BACKGROUND:The authors examined racial/ethnic differences in patient perspectives regarding their breast cancer treatment experiences. METHODS:A weighted random sample of women newly diagnosed with breast cancer between 2013 and 2015 in Los Angeles County and Georgia were sent surveys 2 months after undergoing surgery (5080 women; 70% response rate). The analytic sample was limited to patients residing in Los Angeles County (2397 women). RESULTS:The pattern of visits with different specialists before surgery was found to be similar across racial/ethnic groups. Low acculturated Latinas (Latinas-LA) were less likely to report high clinician communication quality for both surgeons and medical oncologists (<69% vs >72% for all other groups; P<.05). The percentage of patients who reported high satisfaction regarding how physicians worked together was similar across racial/ethnic groups. Latinas-LA were more likely to have a low autonomy decision style (48% vs 24%-50% for all other groups; P<.001) and were more likely to report receiving too much information versus other ethnic groups (20% vs <16% for other groups; P<.001). Patients who reported a low autonomy decision style were more likely to rate the amount of information they received for the surgery decision as "too much" (16% vs 9%; P<.001). CONCLUSIONS:There appears to be moderate disparity in breast cancer treatment communication and decision-making experiences reported by Latinas-LA versus other groups. The approach to treatment decision making by Latinas-LA represents an important challenge to health care providers. Initiatives are needed to improve patient engagement in decision making and increase clinician awareness of these challenges in this patient population. Cancer 2017;123:3022-30. © 2017 American Cancer Society.

SUBMITTER: Katz SJ

PROVIDER: S-EPMC5544545 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Treatment experiences of Latinas after diagnosis of breast cancer.

Katz Steven J SJ Wallner Lauren P LP Abrahamse Paul H PH Janz Nancy K NK Martinez Kathryn A KA Shumway Dean A DA Hamilton Ann S AS Ward Kevin C KC Resnicow Kenneth A KA Hawley Sarah T ST

Cancer 20170411 16

<h4>Background</h4>The authors examined racial/ethnic differences in patient perspectives regarding their breast cancer treatment experiences.<h4>Methods</h4>A weighted random sample of women newly diagnosed with breast cancer between 2013 and 2015 in Los Angeles County and Georgia were sent surveys 2 months after undergoing surgery (5080 women; 70% response rate). The analytic sample was limited to patients residing in Los Angeles County (2397 women).<h4>Results</h4>The pattern of visits with d ...[more]

PMID: 28398629

Similar Datasets

Project description:BACKGROUND:Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report on fine mapping of the 6q25 locus in an expanded sample of Latinas. METHODS:We performed GWAS in 2385 cases and 6416 controls who were either US Latinas or Mexican women. We replicated the top SNPs in 2412 cases and 1620 controls of US Latina, Mexican, and Colombian women. In addition, we validated the top novel variants in studies of African, Asian and European ancestry. In each dataset we used logistic regression models to test the association between SNPs and breast cancer risk and corrected for genetic ancestry using either principal components or genetic ancestry inferred from ancestry informative markers using a model-based approach. RESULTS:We identified a novel set of SNPs at the 6q25 locus associated with genome-wide levels of significance (p?=?3.3?×?10-?8 - 6.0?×?10-?9) not in linkage disequilibrium (LD) with variants previously reported at this locus. These SNPs were in high LD (r2?>?0.9) with each other, with the top SNP, rs3778609, associated with breast cancer with an odds ratio (OR) and 95% confidence interval (95% CI) of 0.76 (0.70-0.84). In a replication in women of Latin American origin, we also observed a consistent effect (OR 0.88; 95% CI 0.78-0.99; p?=?0.037). We also performed a meta-analysis of these SNPs in East Asians, African ancestry and European ancestry populations and also observed a consistent effect (rs3778609, OR 0.95; 95% CI 0.91-0.97; p?=?0.0017). CONCLUSION:Our study adds to evidence about the importance of the 6q25 locus for breast cancer susceptibility. Our finding also highlights the utility of performing additional searches for genetic variants for breast cancer in non-European populations.

Dataset Information

Treatment experiences of Latinas after diagnosis of breast cancer.

Publications

Treatment experiences of Latinas after diagnosis of breast cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure