Neurite elongation is highly correlated with bulk forward translocation of microtubules.
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ABSTRACT:
SUBMITTER: Athamneh AIM
PROVIDER: S-EPMC5544698 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Neurite elongation is highly correlated with bulk forward translocation of microtubules.
Athamneh Ahmad I M AIM He Yingpei Y Lamoureux Phillip P Fix Lucas L Suter Daniel M DM Miller Kyle E KE
Scientific reports 20170804 1
During the development of the nervous system and regeneration following injury, microtubules (MTs) are required for neurite elongation. Whether this elongation occurs primarily through tubulin assembly at the tip of the axon, the transport of individual MTs, or because MTs translocate forward in bulk is unclear. Using fluorescent speckle microscopy (FSM), differential interference contrast (DIC), and phase contrast microscopy, we tracked the movement of MTs, phase dense material, and docked mito ...[more]
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