Effect of Covered Metallic Stents Compared With Plastic Stents on Benign Biliary Stricture Resolution: A Randomized Clinical Trial.

ABSTRACT:

Importance

Endoscopic placement of multiple plastic stents in parallel is the first-line treatment for most benign biliary strictures; it is possible that fully covered, self-expandable metallic stents (cSEMS) may require fewer endoscopic retrograde cholangiopancreatography procedures (ERCPs) to achieve resolution.

Objective

To assess whether use of cSEMS is noninferior to plastic stents with respect to stricture resolution.

Design, setting, and participants

Multicenter (8 endoscopic referral centers), open-label, parallel, randomized clinical trial involving patients with treatment-naive, benign biliary strictures (N = 112) due to orthotopic liver transplant (n = 73), chronic pancreatitis (n = 35), or postoperative injury (n = 4), who were enrolled between April 2011

SUBMITTER: Cote GA 

PROVIDER: S-EPMC5544902 | biostudies-literature | 2016 Mar 22-29

REPOSITORIES: biostudies-literature