Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells.
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ABSTRACT:
SUBMITTER: Tsou LK
PROVIDER: S-EPMC5546009 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells.
Tsou Lun K LK Yount Jacob S JS Hang Howard C HC
Bioorganic & medicinal chemistry 20170310 11
Increasing antibiotic resistance and beneficial effects of host microbiota has motivated the search for anti-infective agents that attenuate bacterial virulence rather than growth. For example, we discovered that specific flavonoids such as baicalein and quercetin from traditional medicinal plant extracts could attenuate Salmonella enterica serovar Typhimurium type III protein secretion and invasion of host cells. Here, we show epigallocatechin-3-gallate from green tea extracts also inhibits the ...[more]
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