Ontology highlight
ABSTRACT:
SUBMITTER: Torolira D
PROVIDER: S-EPMC5546097 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Torolira Daniel D Suchomelova Lucie L Wasterlain Claude G CG Niquet Jerome J
Annals of neurology 20170707 1
Status epilepticus is common in neonates and infants, and is associated with neuronal injury and adverse developmental outcomes. γ-Aminobutyric acidergic (GABAergic) drugs, the standard treatment for neonatal seizures, can have excitatory effects in the neonatal brain, which may worsen the seizures and their effects. Using a recently developed model of status epilepticus in postnatal day 7 rat pups that results in widespread neuronal injury, we found that the GABA<sub>A</sub> agonists phenobarbi ...[more]