Ontology highlight
ABSTRACT:
SUBMITTER: Mastro KJ
PROVIDER: S-EPMC5546121 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Mastro Kevin J KJ Zitelli Kevin T KT Willard Amanda M AM Leblanc Kimberly H KH Kravitz Alexxai V AV Gittis Aryn H AH
Nature neuroscience 20170508 6
The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has remained an untapped resource for therapeutic interventions. Here we demonstrate that optogenetic interventions that dissociate the activity of two neuronal populations in the GPe, ele ...[more]