Ontology highlight
ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC5546151 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wu Lei L Guo Xin X Hartson Steven D SD Davis Mary Abby MA He Hui H Medeiros Denis M DM Wang Weiqun W Clarke Stephen L SL Lucas Edralin A EA Smith Brenda J BJ von Lintig Johannes J Lin Dingbo D
Molecular nutrition & food research 20170209 5
<h4>Scope</h4>β,β-Carotene-9',10'-dioxygenase 2 (BCO2) is a carotenoid cleavage enzyme localized to the inner mitochondrial membrane in mammals. This study was aimed to assess the impact of genetic ablation of BCO2 on hepatic oxidative stress through mitochondrial function in mice.<h4>Methods and results</h4>Liver samples from 6-wk-old male BCO2<sup>-/-</sup> knockout (KO) and isogenic wild-type (WT) mice were subjected to proteomics and functional activity assays. Compared to the WT, KO mice co ...[more]