Cell cycle protein Bora serves as a novel poor prognostic factor in multiple adenocarcinomas.
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ABSTRACT:
SUBMITTER: Zhang QX
PROVIDER: S-EPMC5546444 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Cell cycle protein Bora serves as a novel poor prognostic factor in multiple adenocarcinomas.
Zhang Qiong-Xia QX Gao Rui R Xiang Jin J Yuan Zhong-Yu ZY Qian Yuan-Min YM Yan Min M Wang Zi-Feng ZF Liu Quentin Q Zhao Hai-Dong HD Liu Chang-Hong CH
Oncotarget 20170701 27
Cell cycle protein Bora has been identified to integrate the functions of three major mitotic kinases: Cyclin-dependent kinase-1, Polo-like kinase-1, and Aurora A kinase. Overexpression of Bora disrupts spindle assembly and causes genomic instability. However, the clinical relevance of Bora in cancer remains unclear. In this study, we examined the expression of Bora and its association with clinical characteristics in breast (n = 538), lung (n = 144) and gastric (n = 77) adenocarcinomas. We foun ...[more]
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