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Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial.

ABSTRACT:

SUBMITTER: Durie BGM

PROVIDER: S-EPMC5546834 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial.

Durie Brian G M BGM Hoering Antje A Abidi Muneer H MH Rajkumar S Vincent SV Epstein Joshua J Kahanic Stephen P SP Thakuri Mohan M Reu Frederic F Reynolds Christopher M CM Sexton Rachael R Orlowski Robert Z RZ Barlogie Bart B Dispenzieri Angela A

Lancet (London, England) 20161223 10068

<h4>Background</h4>Lenalidomide plus dexamethasone is a reference treatment for patients with newly diagnosed myeloma. The combination of the proteasome inhibitor bortezomib with lenalidomide and dexamethasone has shown significant efficacy in the setting of newly diagnosed myeloma. We aimed to study whether the addition of bortezomib to lenalidomide and dexamethasone would improve progression-free survival and provide better response rates in patients with previously untreated multiple myeloma ...[more]

PMID: 28017406

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