Ontology highlight
ABSTRACT:
SUBMITTER: Reilly CR
PROVIDER: S-EPMC5547000 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Reilly Christopher R CR Babushok Daria V DV Martin Karlyn K Spivak Jerry L JL Streiff Michael M Bahirwani Ranjeeta R Mondschein Jeffrey J Stein Brady B Moliterno Alison A Hexner Elizabeth O EO
American journal of hematology 20170726 9
BCR-ABL1-negative myeloproliferative neoplasms (MPNs) are clonal stem cell disorders defined by proliferation of one or more myeloid lineages, and carry an increased risk of vascular events and progression to myelofibrosis and leukemia. Portal hypertension (pHTN) occurs in 7-18% of MPN patients via both thrombotic and nonthrombotic mechanisms and portends a poor prognosis. Transjugular intrahepatic portosystemic shunt (TIPS) has been used in the management of MPN-associated pHTN; however, data o ...[more]