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Phenothiazines Enhance Mild Hypothermia-induced Neuroprotection via PI3K/Akt Regulation in Experimental Stroke.

ABSTRACT: Physical hypothermia has long been considered a promising neuroprotective treatment of ischemic stroke, but the treatment's various complications along with the impractical duration and depth of therapy significantly narrow its clinical scope. In the present study, the model of reversible right middle cerebral artery occlusion (MCAO) for 2?h was used. We combined hypothermia (33-35?°C for 1?h) with phenothiazine neuroleptics (chlorpromazine & promethazine) as additive neuroprotectants, with the aim of augmenting its efficacy while only using mild temperatures. We also investigated its therapeutic effects on the Phosphatidylinositol 3 kinase/Protein kinase B (PI3K/Akt) apoptotic pathway. The combination treatment achieved reduction in ischemic rat temperatures in the rectum, cortex and striatum significantly (P?

SUBMITTER: An H

PROVIDER: S-EPMC5547051 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Phenothiazines Enhance Mild Hypothermia-induced Neuroprotection via PI3K/Akt Regulation in Experimental Stroke.

An Hong H Duan Yunxia Y Wu Di D Yip James J Elmadhoun Omar O Wright Joshua C JC Shi Wenjuan W Liu Kaiyin K He Xiaoduo X Shi Jingfei J Jiang Fang F Ji Xunming X Ding Yuchuan Y

Scientific reports 20170807 1

Physical hypothermia has long been considered a promising neuroprotective treatment of ischemic stroke, but the treatment's various complications along with the impractical duration and depth of therapy significantly narrow its clinical scope. In the present study, the model of reversible right middle cerebral artery occlusion (MCAO) for 2 h was used. We combined hypothermia (33-35 °C for 1 h) with phenothiazine neuroleptics (chlorpromazine & promethazine) as additive neuroprotectants, with the ...[more]

PMID: 28785051

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