Ontology highlight
ABSTRACT:
SUBMITTER: Lai M
PROVIDER: S-EPMC5547127 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Lai Michele M Realini Natalia N La Ferla Marco M Passalacqua Ilaria I Matteoli Giulia G Ganesan Anand A Pistello Mauro M Mazzanti Chiara Maria CM Piomelli Daniele D
Scientific reports 20170807 1
Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers intracellular ceramide levels and concomitantly generates sphingosine used for sphingosine-1-phosphate (S1P) production. Since increases in ceramide and consequent decreases of S1P reduce proliferation of various cancers, AC might offer a new target for anti-tumor therapy. Here we used CrispR-Cas9-mediated gene editing to delete the gene encoding ...[more]