Ontology highlight
ABSTRACT:
SUBMITTER: Bartlett SL
PROVIDER: S-EPMC5547566 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170615 25
An enantioselective [3 + 2] cycloaddition reaction between nitrile oxides and transiently generated enolates of α-keto esters has been developed. The catalyst system was found to be compatible with in situ nitrile oxide-generation conditions. A versatile array of nitrile oxides and α-keto esters could participate in the cycloaddition, providing novel 5-hydroxy-2-isoxazolines in high chemical yield with high levels of diastereo- and enantioselectivity. Notably, the optimal reaction conditions cir ...[more]