Ontology highlight
ABSTRACT:
SUBMITTER: Tran NH
PROVIDER: S-EPMC5547637 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Tran Ngoc Hieu NH Zhang Xianglilan X Xin Lei L Shan Baozhen B Li Ming M
Proceedings of the National Academy of Sciences of the United States of America 20170718 31
De novo peptide sequencing from tandem MS data is the key technology in proteomics for the characterization of proteins, especially for new sequences, such as mAbs. In this study, we propose a deep neural network model, DeepNovo, for de novo peptide sequencing. DeepNovo architecture combines recent advances in convolutional neural networks and recurrent neural networks to learn features of tandem mass spectra, fragment ions, and sequence patterns of peptides. The networks are further integrated ...[more]