Ontology highlight
ABSTRACT:
SUBMITTER: Miller JL
PROVIDER: S-EPMC5548239 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Miller Jennifer L JL Strong Theresa V TV Heinemann Janalee J
Diseases (Basel, Switzerland) 20150603 2
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the absence of paternally expressed, imprinted genes on chromosome 15q11-13. Individuals with PWS characteristically have poor feeding and lack of appetite in infancy, followed by the development of weight gain and then uncontrolled appetite and lack of satiety, sometime after the age of two. The overwhelming drive to eat is coupled with reduced energy expenditure and decreased caloric requirements, thus, individuals with PWS ...[more]