Ontology highlight
ABSTRACT:
SUBMITTER: Guallar V
PROVIDER: S-EPMC554833 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Guallar Victor V Borrelli Kenneth W KW
Proceedings of the National Academy of Sciences of the United States of America 20050307 11
We present a close electronic view of the protein-base interface for the N-terminal domain of the human protein U1A. Combining accurate mixed quantum mechanics/molecular mechanics techniques and protein structure prediction methods, we provide a detailed electronic structure description of the protein-RNA stacking interactions. Our analysis indicates the evolution of the protein structure optimizing the interaction between Asp-92 and the RNA bases. The results show a direct coupling of the C-ter ...[more]