Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC5548460 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Liu Fan F Wang Lan L Perna Fabiana F Nimer Stephen D SD
Nature reviews. Cancer 20160601 6
Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations in, or altered expression of, chromatin modifiers. Recent reports on the interplay between cellular signalling pathways and chromatin modifications add another layer of complexity to the already ...[more]