Ontology highlight
ABSTRACT:
SUBMITTER: Friedlander T
PROVIDER: S-EPMC5548793 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Friedlander Tamar T Prizak Roshan R Barton Nicholas H NH Tkačik Gašper G
Nature communications 20170809 1
Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isolated genetic elements. In contrast, we study the essential process by which regulatory networks grow: the duplication and subsequent specialization of network components. We synthesize a biophysical mo ...[more]