Ontology highlight
ABSTRACT:
SUBMITTER: Papillon-Cavanagh S
PROVIDER: S-EPMC5549104 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20170109 2
Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs) are deadly and common cancers. Recent genomic studies implicate multiple genetic pathways, including cell signaling, cell cycle and immune evasion, in their development. Here we analyze public data sets and uncover a previously unappreciated role of epigenome deregulation in the genesis of 13% of HPV-negative HNSCCs. Specifically, we identify novel recurrent mutations encoding p.Lys36Met (K36M) alterations in mul ...[more]