Ontology highlight
ABSTRACT:
SUBMITTER: Hou HA
PROVIDER: S-EPMC5549259 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Hou H-A HA Lu J-W JW Lin T-Y TY Tsai C-H CH Chou W-C WC Lin C-C CC Kuo Y-Y YY Liu C-Y CY Tseng M-H MH Chiang Y-C YC Peng Y-L YL Tang J-L JL Gong Z Z Lin L-I LI Tien H-F HF
Blood cancer journal 20170728 7
Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. The mechanism of SOCS1 in tumor carcinogenesis is complex and there have been no studies concerning the clinic-biologic implication of SOCS1 expression in acute myeloid leukemia (AML). Here, we first identified that higher bone marrow (BM) SOCS1 expression was closely associated with older a ...[more]