Decarboxylation Study of Acidic Cannabinoids: A Novel Approach Using Ultra-High-Performance Supercritical Fluid Chromatography/Photodiode Array-Mass Spectrometry.

ABSTRACT: Introduction: Decarboxylation is an important step for efficient production of the major active components in cannabis, for example, Δ⁹-tetrahydrocannabinol (Δ⁹-THC), cannabidiol (CBD), and cannabigerol (CBG). These cannabinoids do not occur in significant concentrations in cannabis but can be formed by decarboxylation of their corresponding acids, the predominant cannabinoids in the plant. Study of the kinetics of decarboxylation is of importance for phytocannabinoid isolation and dosage formulation for medical use. Efficient analytical methods are essential for simultaneous detection of both neutral and acidic cannabinoids. Methods:C. sativa extracts were used for the studies. Decarboxylation conditions were examined at 80°C, 95°C, 110°C, 130°C,

SUBMITTER: Wang M 

PROVIDER: S-EPMC5549281 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature