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Mechanistic insights into selective autophagy pathways: lessons from yeast.

ABSTRACT: Autophagy has burgeoned rapidly as a field of study because of its evolutionary conservation, the diversity of intracellular cargoes degraded and recycled by this machinery, the mechanisms involved, as well as its physiological relevance to human health and disease. This self-eating process was initially viewed as a non-selective mechanism used by eukaryotic cells to degrade and recycle macromolecules in response to stress; we now know that various cellular constituents, as well as pathogens, can also undergo selective autophagy. In contrast to non-selective autophagy, selective autophagy pathways rely on a plethora of selective autophagy receptors (SARs) that recognize and direct intracellular protein aggregates, organelles and pathogens for specific degradation. Although SARs themselves are not highly conserved, their modes of action and the signalling cascades that activate and regulate them are. Recent yeast studies have provided novel mechanistic insights into selective autophagy pathways, revealing principles of how various cargoes can be marked and targeted for selective degradation.

SUBMITTER: Farre JC

PROVIDER: S-EPMC5549613 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Mechanistic insights into selective autophagy pathways: lessons from yeast.

Farré Jean-Claude JC Subramani Suresh S

Nature reviews. Molecular cell biology 20160706 9

Autophagy has burgeoned rapidly as a field of study because of its evolutionary conservation, the diversity of intracellular cargoes degraded and recycled by this machinery, the mechanisms involved, as well as its physiological relevance to human health and disease. This self-eating process was initially viewed as a non-selective mechanism used by eukaryotic cells to degrade and recycle macromolecules in response to stress; we now know that various cellular constituents, as well as pathogens, ca ...[more]

PMID: 27381245

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Mechanistic insights into selective autophagy pathways: lessons from yeast.

Publications

Mechanistic insights into selective autophagy pathways: lessons from yeast.

Similar Datasets

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