Ontology highlight
ABSTRACT:
SUBMITTER: Buchumenski I
PROVIDER: S-EPMC5550009 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Buchumenski Ilana I Bartok Osnat O Ashwal-Fluss Reut R Pandey Varun V Porath Hagit T HT Levanon Erez Y EY Kadener Sebastian S
PLoS genetics 20170726 7
In Drosophila, A-to-I editing is prevalent in the brain, and mutations in the editing enzyme ADAR correlate with specific behavioral defects. Here we demonstrate a role for ADAR in behavioral temperature adaptation in Drosophila. Although there is a higher level of editing at lower temperatures, at 29°C more sites are edited. These sites are less evolutionarily conserved, more disperse, less likely to be involved in secondary structures, and more likely to be located in exons. Interestingly, hyp ...[more]