Ontology highlight
ABSTRACT:
SUBMITTER: Tcw J
PROVIDER: S-EPMC5550034 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Stem cell reports 20170727 2
Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from human induced pluripotent stem cells (hiPSCs), via a neural progenitor cell (NPC) intermediate. We evaluated this protocol across 42 NPC lines (derived from 30 individuals). Transcriptomic analysis demonstrated that hiPSC-astrocytes from four individuals ...[more]