Ontology highlight
ABSTRACT:
SUBMITTER: Pol SU
PROVIDER: S-EPMC5550273 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Pol Suyog U SU Polanco Jessie J JJ Seidman Richard A RA O'Bara Melanie A MA Shayya Hani J HJ Dietz Karen C KC Sim Fraser J FJ
Stem cell reports 20170801 2
Impaired human oligodendrocyte progenitor cell (hOPC) differentiation likely contributes to failed remyelination in multiple sclerosis. The characterization of molecular pathways that regulate hOPC differentiation will provide means to induce remyelination. In this study, we determined the gene expression profile of PDGFαR<sup>+</sup> hOPCs during initial oligodendrocyte commitment. Weighted gene coexpression network analysis was used to define progenitor and differentiation-specific gene expres ...[more]