Ontology highlight
ABSTRACT:
SUBMITTER: Cuevas RA
PROVIDER: S-EPMC5550342 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Cuevas Rolando A RA Eutsey Rory R Kadam Anagha A West-Roberts Jacob A JA Woolford Carol A CA Mitchell Aaron P AP Mason Kevin M KM Hiller N Luisa NL
Molecular microbiology 20170623 4
Streptococcus pneumoniae (pneumococcus) is a major human pathogen. It is a common colonizer of the human respiratory track, where it utilizes cell-cell communication systems to coordinate population-level behaviors. We reasoned that secreted peptides that are highly expressed during infection are pivotal for virulence. Thus, we used in silico pattern searches to define a pneumococcal secretome and analyzed the transcriptome of the clinically important PMEN1 lineage to identify which peptide-enco ...[more]