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Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice.

ABSTRACT: The relationship between marrow adipose tissue (MAT) and bone health is poorly understood. We used running exercise to ask whether obesity-associated MAT can be attenuated via exercise and whether this correlates with gains in bone quantity and quality. C57BL/6 mice were divided into diet-induced obesity (DIO, n?=?14) versus low-fat diet (LFD, n?=?14). After 3 months, 16-week-old mice were allocated to an exercise intervention (LFD-E, DIO-E) or a control group (LFD, DIO) for 6 weeks (4 groups, n?=?7/group). Marrow adipocyte area was 44% higher with obesity (p?

SUBMITTER: Styner M

PROVIDER: S-EPMC5550355 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice.

Styner Maya M Pagnotti Gabriel M GM McGrath Cody C Wu Xin X Sen Buer B Uzer Gunes G Xie Zhihui Z Zong Xiaopeng X Styner Martin A MA Rubin Clinton T CT Rubin Janet J

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20170504 8

The relationship between marrow adipose tissue (MAT) and bone health is poorly understood. We used running exercise to ask whether obesity-associated MAT can be attenuated via exercise and whether this correlates with gains in bone quantity and quality. C57BL/6 mice were divided into diet-induced obesity (DIO, n = 14) versus low-fat diet (LFD, n = 14). After 3 months, 16-week-old mice were allocated to an exercise intervention (LFD-E, DIO-E) or a control group (LFD, DIO) for 6 weeks (4 groups, n ...[more]

PMID: 28436105

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