Ontology highlight
ABSTRACT:
SUBMITTER: Jeanne A
PROVIDER: S-EPMC5550434 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Jeanne Albin A Untereiner Valérie V Perreau Corinne C Proult Isabelle I Gobinet Cyril C Boulagnon-Rombi Camille C Terryn Christine C Martiny Laurent L Brézillon Stéphane S Dedieu Stéphane S
Scientific reports 20170809 1
Lumican is a small leucine-rich proteoglycan (SLRP) being known as a key regulator of collagen fibrillogenesis. However, little attention has been given so far in studying its influence on tumor-associated matrix architecture. Here, we investigate the role of host lumican on tumor matrix organization as well as on disease progression considering an immunocompetent model of melanoma implanted in Lum <sup>-/-</sup> vs. wild type syngeneic mice. Conjointly, lumican impact on tumor response to matri ...[more]