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A cell-based mechanical model of coronary artery tunica media.


ABSTRACT: A three-dimensional cell-based mechanical model of coronary artery tunica media is proposed. The model is composed of spherical cells forming a hexagonal close-packed lattice. Tissue anisotropy is taken into account by varying interaction forces with the direction of intercellular connection. Several cell-centre interaction potentials for repulsion and attraction are considered, including the Hertz contact model and its neo-Hookean extension, the Johnson-Kendall-Roberts model of adhesive contact, and a wormlike chain model. The model is validated against data from in vitro uni-axial tension tests performed on dissected strips of tunica media. The wormlike chain potential in combination with the neo-Hookean Hertz contact model produces stress-stretch curves which represent the experimental data very well.

SUBMITTER: Melnikova NB 

PROVIDER: S-EPMC5550961 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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A cell-based mechanical model of coronary artery tunica media.

Melnikova N B NB   Svitenkov A I AI   Hose D R DR   Hoekstra A G AG  

Journal of the Royal Society, Interface 20170701 132


A three-dimensional cell-based mechanical model of coronary artery tunica media is proposed. The model is composed of spherical cells forming a hexagonal close-packed lattice. Tissue anisotropy is taken into account by varying interaction forces with the direction of intercellular connection. Several cell-centre interaction potentials for repulsion and attraction are considered, including the Hertz contact model and its neo-Hookean extension, the Johnson-Kendall-Roberts model of adhesive contact  ...[more]

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