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DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.

ABSTRACT: The p33ING1 protein is a regulator of cell cycle, senescence, and apoptosis. Three alternatively spliced transcripts of p33ING1 encode p47ING1a, p33ING1b, and p24ING1c. We cloned an additional ING family member, p33ING2/ING1L. Unlike p33ING1b, p33ING2 is induced by the DNA-damaging agents etoposide and neocarzinostatin. p33ING1b and p33ING2 negatively regulate cell growth and survival in a p53-dependent manner through induction of G(1)-phase cell-cycle arrest and apoptosis. p33ING2 strongly enhances the transcriptional-transactivation activity of p53. Furthermore, p33ING2 expression increases the acetylation of p53 at Lys-382. Taken together, p33ING2 is a DNA damage-inducible gene that negatively regulates cell proliferation through activation of p53 by enhancing its acetylation.

SUBMITTER: Nagashima M

PROVIDER: S-EPMC55510 | biostudies-literature | 2001 Aug

REPOSITORIES: biostudies-literature

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DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.

Nagashima M M Shiseki M M Miura K K Hagiwara K K Linke S P SP Pedeux R R Wang X W XW Yokota J J Riabowol K K Harris C C CC

Proceedings of the National Academy of Sciences of the United States of America 20010731 17

The p33ING1 protein is a regulator of cell cycle, senescence, and apoptosis. Three alternatively spliced transcripts of p33ING1 encode p47ING1a, p33ING1b, and p24ING1c. We cloned an additional ING family member, p33ING2/ING1L. Unlike p33ING1b, p33ING2 is induced by the DNA-damaging agents etoposide and neocarzinostatin. p33ING1b and p33ING2 negatively regulate cell growth and survival in a p53-dependent manner through induction of G(1)-phase cell-cycle arrest and apoptosis. p33ING2 strongly enha ...[more]

PMID: 11481424

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