Ontology highlight
ABSTRACT:
SUBMITTER: Brito-Zeron P
PROVIDER: S-EPMC5551504 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Brito-Zerón Pilar P Izmirly Peter M PM Ramos-Casals Manuel M Buyon Jill P JP Khamashta Munther A MA
Nature reviews. Rheumatology 20150324 5
Autoimmune congenital heart block (CHB) is an immune-mediated acquired disease that is associated with the placental transference of maternal antibodies specific for Ro and La autoantigens. The disease develops in a fetal heart without anatomical abnormalities that could otherwise explain the block, and which is usually diagnosed in utero, but also at birth or within the neonatal period. Autoantibody-mediated damage of fetal conduction tissues causes inflammation and fibrosis and leads to blocka ...[more]