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Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension.


ABSTRACT: As pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, particularly among patients with right ventricular (RV) dysfunction, we aimed to determine the impact of therapy to reduce pulmonary vascular resistance (PVR) on RV and LV deformation in PAH.Right ventricular free wall longitudinal strain (FWLS) and LV global circumferential strain (CS) were measured at baseline, 12 weeks, and 24 weeks in 68 patients with advanced PAH randomized to imatinib or placebo in the Imatinib in Pulmonary arterial hypertension, a Randomized Efficacy Study (IMPRES) trial, and compared with 30 healthy controls. Compared with controls, PAH was associated with impaired RV FWLS (-15.9?±?5.4 vs. -30.8?±?4.3, respectively; P?

SUBMITTER: Querejeta Roca G 

PROVIDER: S-EPMC5551563 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension.

Querejeta Roca Gabriela G   Campbell Patricia P   Claggett Brian B   Vazir Ali A   Quinn Debbie D   Solomon Scott D SD   Shah Amil M AM  

European journal of heart failure 20141104 1


<h4>Aims</h4>As pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, particularly among patients with right ventricular (RV) dysfunction, we aimed to determine the impact of therapy to reduce pulmonary vascular resistance (PVR) on RV and LV deformation in PAH.<h4>Methods and results</h4>Right ventricular free wall longitudinal strain (FWLS) and LV global circumferential strain (CS) were measured at baseline, 12 weeks, and 24 weeks in 68 patients with adva  ...[more]

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