Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants.
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ABSTRACT:
SUBMITTER: Einav T
PROVIDER: S-EPMC5551692 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants.
The journal of physical chemistry. B 20170221 15
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration ([EC<sub>50</sub>]), and effective Hill coefficient, and explore the full spectrum of phenotypes that are accessible through mutations. Specifically, we consider mutations in the channel pore of nicotinic ace ...[more]
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