Ontology highlight
ABSTRACT:
SUBMITTER: Graziano BR
PROVIDER: S-EPMC5551696 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Graziano Brian R BR Gong Delquin D Anderson Karen E KE Pipathsouk Anne A Goldberg Anna R AR Weiner Orion D OD
The Journal of cell biology 20170707 8
Sensory systems use adaptation to measure changes in signaling inputs rather than absolute levels of signaling inputs. Adaptation enables eukaryotic cells to directionally migrate over a large dynamic range of chemoattractant. Because of complex feedback interactions and redundancy, it has been difficult to define the portion or portions of eukaryotic chemotactic signaling networks that generate adaptation and identify the regulators of this process. In this study, we use a combination of optoge ...[more]