Ontology highlight
ABSTRACT:
SUBMITTER: Nowakowski GS
PROVIDER: S-EPMC5551933 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nowakowski Grzegorz S GS Chiappella Annalisa A Witzig Thomas E TE Spina Michele M Gascoyne Randy D RD Zhang Lei L Flament Jocelyne J Repici Jacqueline J Vitolo Umberto U
Future oncology (London, England) 20160418 13
Activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL), the major constituent of nongerminal center B-cell-like (non-GCB) DLBCL, is associated with poorer survival outcomes than GCB-type DLBCL. In Phase II studies, lenalidomide combined with R-CHOP (R(2)-CHOP) improved outcomes relative to historical R-CHOP in newly diagnosed DLBCL, particularly in non-GCB cases. ROBUST (CC-5013-DLC-002) is a randomized, double-blind, global, Phase III study of oral lenalidomide (15 mg, days 1-14) plu ...[more]