Transcriptome and proteome analysis of Salmonella enterica serovar Typhimurium systemic infection of wild type and immune-deficient mice.
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ABSTRACT:
SUBMITTER: Oshota O
PROVIDER: S-EPMC5552096 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Transcriptome and proteome analysis of Salmonella enterica serovar Typhimurium systemic infection of wild type and immune-deficient mice.
Oshota Olusegun O Conway Max M Fookes Maria M Schreiber Fernanda F Chaudhuri Roy R RR Yu Lu L Morgan Fiona J E FJE Clare Simon S Choudhary Jyoti J Thomson Nicholas R NR Lio Pietro P Maskell Duncan J DJ Mastroeni Pietro P Grant Andrew J AJ
PloS one 20170810 8
Salmonella enterica are a threat to public health. Current vaccines are not fully effective. The ability to grow in infected tissues within phagocytes is required for S. enterica virulence in systemic disease. As the infection progresses the bacteria are exposed to a complex host immune response. Consequently, in order to continue growing in the tissues, S. enterica requires the coordinated regulation of fitness genes. Bacterial gene regulation has so far been investigated largely using exposure ...[more]
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