Suppression of Beneficial Mutations in Dynamic Microbial Populations.
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ABSTRACT:
SUBMITTER: Bittihn P
PROVIDER: S-EPMC5552243 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Suppression of Beneficial Mutations in Dynamic Microbial Populations.
Bittihn Philip P Hasty Jeff J Tsimring Lev S LS
Physical review letters 20170112 2
Quantitative predictions for the spread of mutations in bacterial populations are essential to interpret evolution experiments and to improve the stability of synthetic gene circuits. We derive analytical expressions for the suppression factor for beneficial mutations in populations that undergo periodic dilutions, covering arbitrary population sizes, dilution factors, and growth advantages in a single stochastic model. We find that the suppression factor grows with the dilution factor and depen ...[more]
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