Ontology highlight
ABSTRACT:
SUBMITTER: Fontana P
PROVIDER: S-EPMC5552275 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Fontana Pietro P Bonfiglio Juan José JJ Palazzo Luca L Bartlett Edward E Matic Ivan I Ahel Ivan I
eLife 20170626
ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and hydrolysis of ADPr, and also specify how and when the modification is conjugated to the targets. We recently discovered a new form of ADPr that is attached to serine residues in target proteins (Ser-ADPr) and showed that this PTM is specifically made by PARP1/HPF1 ...[more]