Ontology highlight
ABSTRACT: Conclusion
Glutamine metabolism plays an important role in regulating the proliferation and activation of HSCs. Strategies that are targeted at glutamine metabolism may represent a novel therapeutic approach to the treatment of liver fibrosis.
SUBMITTER: Li J
PROVIDER: S-EPMC5552314 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Li Jiang J Ghazwani Mohammed M Liu Ke K Huang Yixian Y Chang Na N Fan Jie J He Fengtian F Li Liying L Bu Shizhong S Xie Wen W Ma Xiaochao X Li Song S
PloS one 20170810 8
Liver fibrosis is the excessive accumulation of extracellular matrix proteins, which is mainly caused by accumulation of activated hepatic stellate cells (HSCs). The mechanisms of activation and proliferation of HSCs, two key events after liver damage, have been studied for many years. Here we report a novel pathway to control HSCs by regulating glutamine metabolism. We demonstrated that the proliferation of HSCs is critically dependent on glutamine that is used to generate α-ketoglutarate (α-KG ...[more]