Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC5552321 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Li Guangming G Zhao Juanjuan J Cheng Liang L Jiang Qi Q Kan Sheng S Qin Enqiang E Tu Bo B Zhang Xin X Zhang Liguo L Su Lishan L Zhang Zheng Z
PLoS pathogens 20170731 7
Chronic human immunodeficiency virus-1 (HIV-1) infection in patients leads to multi-lineage hematopoietic abnormalities or pancytopenia. The deficiency in hematopoietic progenitor cells (HPCs) induced by HIV-1 infection has been proposed, but the relevant mechanisms are poorly understood. We report here that both human CD34+CD38- early and CD34+CD38+ intermediate HPCs were maintained in the bone marrow (BM) of humanized mice. Chronic HIV-1 infection preferentially depleted CD34+CD38- early HPCs ...[more]