Unknown

Dataset Information

0

Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery.


ABSTRACT: BackgroundMaternal breast milk (MBM) is enriched in microRNAs, factors that regulate protein translation throughout the human body. MBM from mothers of term and preterm infants differs in nutrient, hormone, and bioactive-factor composition, but the microRNA differences between these groups have not been compared. We hypothesized that gestational age at delivery influences microRNA in MBM, particularly microRNAs involved in immunologic and metabolic regulation.MethodsMBM from mothers of premature infants (pMBM) obtained 3-4 weeks post delivery was compared with MBM from mothers of term infants obtained at birth (tColostrum) and 3-4 weeks post delivery (tMBM). The microRNA profile in lipid and skim fractions of each sample was evaluated with high-throughput sequencing.ResultsThe expression profiles of nine microRNAs in lipid and skim pMBM differed from those in tMBM. Gene targets of these microRNAs were functionally related to elemental metabolism and lipid biosynthesis. The microRNA profile of tColostrum was also distinct from that of pMBM, but it clustered closely with tMBM. Twenty-one microRNAs correlated with gestational age demonstrated limited relationships with method of delivery, but not other maternal-infant factors.ConclusionPremature delivery results in a unique MBM microRNA profile with metabolic targets. This suggests that preterm milk may have adaptive functions for growth in premature infants.

SUBMITTER: Carney MC 

PROVIDER: S-EPMC5552431 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery.

Carney Molly C MC   Tarasiuk Andrij A   DiAngelo Susan L SL   Silveyra Patricia P   Podany Abigail A   Birch Leann L LL   Paul Ian M IM   Kelleher Shannon S   Hicks Steven D SD  

Pediatric research 20170524 2


BackgroundMaternal breast milk (MBM) is enriched in microRNAs, factors that regulate protein translation throughout the human body. MBM from mothers of term and preterm infants differs in nutrient, hormone, and bioactive-factor composition, but the microRNA differences between these groups have not been compared. We hypothesized that gestational age at delivery influences microRNA in MBM, particularly microRNAs involved in immunologic and metabolic regulation.MethodsMBM from mothers of premature  ...[more]

Similar Datasets

| S-EPMC3248653 | biostudies-literature
2011-12-21 | GSE32253 | GEO
2011-12-21 | E-GEOD-32253 | biostudies-arrayexpress
| S-EPMC10534677 | biostudies-literature
| S-EPMC8796169 | biostudies-literature
| S-EPMC9266562 | biostudies-literature
| S-EPMC4426237 | biostudies-literature
| S-EPMC4583031 | biostudies-literature
| S-EPMC5471263 | biostudies-literature
| S-EPMC7230887 | biostudies-literature